509-335-3794, lange-m@wsu.edu

Ph.D. 1995, University of Munich, Germany
M.S. 1991, University of Bonn, Germany
B.S. 1988, University of Bonn, Germany

Lange laboratory website: http://www.wsu.edu/~lange-m/index.html

Research Interests

Plants produce a diverse array of metabolites, the majority of which does not appear to be directly involved in growth and development. These metabolites are commonly referred to as secondary metabolites, specialized metabolites or natural products. In contrast to primary metabolites, which are found in all plants and are usually involved in essential processes (e.g., acyl lipids, amino acids, chlorophylls, hormones, nucleotides, organic acids, phytosterols, sugar phosphates, vitamins), natural products oftentimes play more elusive roles in the communication of plants with their environment (e.g., protection against herbivores and infection and attraction of pollinators and/or seed dispersers) and are differentially distributed. Plant natural products are better known for their utility as dyes (e.g., indigo), fibers (e.g., cellulose), flavors (e.g., d-limonene from Citrus), fragrances (e.g., geraniol from Damask rose), and drugs (e.g., morphine). Research in the Lange laboratory is aimed at characterizing the interface between primary and secondary metabolic pathways using functional genomics and systems biology approaches.

Current projects

• Crosstalk between cytosolic and plastidial pathways of isoprenoid biosynthesis
  Metabolism in specialized cells (in particular: glandular trichomes and soybean paraveinal mesophyll)
• Development of metabolite profiling assays
• Development of tools for the integration of post-genomic data sets
• Development of mathematical models for metabolic pathways

Selected Publications

Lange, B.M. 2006. Biotechnology of isoprenoid production. In "Plant Genetic Engineering Vol. 7: Metabolic Engineering & Molecular Farming", Jaiwal, P.K. eds., pp 261-277. Houston, TX: Studium Press LLC.

Lange B.M. 2006. Integrative analysis of metabolic networks: From peaks to flux models? Curr. Op. Plant Biol. 9:220-226.

Mandaokar A., Thines B., Shin B., Lange B.M., Choi G., Koo Y.J., Yoo Y.J., Choi Y.D., Choi G., Browse J. 2006. Transcriptional regulators of stamen development in Arabidopsis identified by transcriptional profiling. Plant J. 46:984-1008.

Ghassemian M., Lutes J., Tepperman J.M., Chang H.S., Zhu T., Wang X., Quail P.H., Lange B.M. 2006. Integrative analysis of transcript and metabolite profiling data sets to evaluate the regulation of biochemical pathways during photomorphogenesis Arch. Biochem. Biophys. 448:45-59.

Lange B.M. 2005. Biotechnology of isoprenoid production. In Improving the Nutritional and Therapeutic Qualities of Plants, Jaiwal, P.K., ed., Haworth Press Inc., New York, in press.

Lange B.M. 2005. Single-cell genomics. Curr. Op. Plant Biol. 8:236-241.

Lange B.M., Ghassemian M. 2005. Comprehensive post-genomic data analysis approaches integrating biochemical pathway maps. Phytochemistry 66:413-451.

Browse J., Lange B.M. 2004. Counting the cost of a cold-blooded life. Proc. Natl. Acad. Sci. USA 101:14996-14997.

Jenkins H., Hardy N., Beckmann M., Draper J., Smith A.R., Taylor J., Fiehn O., Goodacre R., Bino R., Hall R., Kopka J., Lange B.M., Liu J.R., Mendes P., Nikolau B.J., Oliver S.G., Paton N.W., Roessner-Tunali U., Saito K., Smedsgaard J., Sumner L.W., Wurtele E.S., Kell D.B. 2004. A proposed framework for the description of plant metabolomics experiments and their results. Nature Biotechnol. 22:1601-1606.

Bino R.J., Hall R.D., Fiehn O., Kopka J., Saito K., Draper J., Nikolau B.J., Mendes P., Roessner-Tunali U., Beale M.H., Trethewey R.N., Lange B.M., Wurtele E.S., Sumner L.W. 2004. Potential of metabolomics as a functional genomics tool. Trends Plant Sci. 9:418-425.

Bick J.A., Lange B.M. 2003. Metabolic cross talk between cytosolic and plastidial pathways of isoprenoid biosynthesis: unidirectional transport of intermediates across the chloroplast envelope membrane. Arch. Biochem. Biophys. 415:146-154.

Laule O., Führholz A., Chang H.S., Zhu T., Wang X., Heifetz P.B., Gruissem W., Lange B.M. 2003. Crosstalk between cytosolic and plastidial pathways of isoprenoid biosynthesis in Arabidopsis thaliana. Proc. Natl. Acad. Sci. USA 100:6866-6871.

Koller A., Washburn M.P., Lange B.M., Andon N.L., Deciu C., Haynes P.A., Hays L., Schieltz D., Ulaszek R., Wei J., Wolters D., Yates J.R. 2002. Proteomic survey of metabolic pathways in rice, Proc. Natl. Acad. Sci. USA 99:11969-11974 (COVER STORY).

Goff S.A., Ricke D., Lan T.H., Presting G., Wang R., Dunn M., Glazebrook J., Sessions A., Oeller P., Varma H., Hadley D., Hutchison D., Martin C., Katagiri F., Lange B.M. et al. 2002. A draft sequence of the rice genome (Oryza sativa L. ssp. japonica), Science 296:92-100 (COVER STORY).

Lange B.M., Ketchum R.E.B., Croteau R. 2001. Isoprenoid biosynthesis: metabolite profiling of peppermint oil gland secretory cells and application to herbicide target analysis, Plant Physiol. 127:305-314.

Lange, B.M., Rujan, T., Martin, W., Croteau, R. 2000. Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes, Proc. Natl. Acad. Sci. USA 97:13172-13177.

Lange B.M., Wildung M.R., Stauber E., Sanchez C., Pouchnik D., Croteau R. 2000. Probing essential oil biosynthesis and storage by evaluation of expressed sequence tags from mint glandular trichomes, Proc. Natl. Acad. Sci. USA 97:2934-2939.